Review
doi: 10.1111/j.1365-2680.1999.tb00005.x.
The human desipramine-sensitive noradrenaline transporter and the importance of defined amino acids for its function
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- PMID: 10961738
- DOI: 10.1111/j.1365-2680.1999.tb00005.x
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Review
The human desipramine-sensitive noradrenaline transporter and the importance of defined amino acids for its function
J Auton Pharmacol.
1999 Dec.
Abstract
1. This article gives a short overview of the physiology, pharmacology and the molecular biology of the human Na+/Cl(-)-dependent noradrenaline transporter (hNAT) and its gene. 2. Furthermore, naturally occurring variants of the hNAT are described and new results obtained through site-directed mutagenesis of the hNAT are presented, which increase our understanding about structural domains and amino acids critically involved in substrate, cosubstrate and inhibitor binding to the hNAT.
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