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Review
. 2000 Feb;21(2):139-51.
doi: 10.1023/a:1005610007209.

Variable surface loops and myosin activity: accessories to a motor

C T Murphy  1 , J A Spudich
Affiliations
Review

Variable surface loops and myosin activity: accessories to a motor

C T Murphy et al. J Muscle Res Cell Motil. 2000 Feb.

Abstract

The catalytic head of myosin is a globular structure that has historically been divided into three segments of 25, 50, and 20 kDa. The solvent-exposed, proteolytically-sensitive surface loops of myosin that join these three segments are highly variable in their sequences. While surface loops have not traditionally been thought to affect enzymatic activities, these loops lie near the ATP and actin-binding sites and have been implicated in the modulation of myosin's kinetic activities. In this work we review the wealth of data regarding the loops that has accumulated over the years and discuss the roles of the loops in contributing to the different activities displayed by different myosin isoforms.

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References

    1. J Biol Chem. 1993 Feb 5;268(4):2410-5 - PubMed
    1. J Mol Biol. 1996 Jan 12;255(1):98-109 - PubMed
    1. Science. 1998 Jan 23;279(5350):527-33 - PubMed
    1. J Biol Chem. 1998 Oct 23;273(43):27939-44 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Feb;82(3):658-62 - PubMed

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