A double-blind cross-over trail of Prenazone and aspirin in the management of rheumatoid arthritis
- PMID: 1096275
- DOI: 10.1093/rheumatology/14.2.61
A double-blind cross-over trail of Prenazone and aspirin in the management of rheumatoid arthritis
Abstract
A double-blind cross-over trial of Prenazone 600 mg and Aspirin 4 g daily was carried out on 20 patients suffering with rheumatoid arthritis. The analgesic and anti-inflammmatory activity was indistinguishable from that of aspirin under the conditions of the trail. Twelve patients expressed a general preference for Prenazone and six for aspirin. Prenazone appeared to be well tolerated and free from serious side-effects. These results suggest that it will be a useful drug in the management of rheumatoid arthritis.
Similar articles
-
A double-blind cross-over trial of Prenazone (DA 2370) and phenylbutazone in rheumatoid arthritis.Rheumatol Rehabil. 1975 May;14(2):67-70. doi: 10.1093/rheumatology/14.2.67. Rheumatol Rehabil. 1975. PMID: 1096276 Clinical Trial.
-
Feprazone compared with indomethacin in the management of rheumatoid arthritis.Practitioner. 1975 Jul;215(1285):94-7. Practitioner. 1975. PMID: 1103113 Clinical Trial.
-
Comparison of sulindac and aspirin in rheumatoid arthritis.Curr Med Res Opin. 1977;4(7):485-91. doi: 10.1185/03007997709109337. Curr Med Res Opin. 1977. PMID: 321183 Clinical Trial.
-
[Pharmacodynamics and adverse effects of modern nonsteroid anti-inflammatory agents].Ter Arkh. 1981;53(7):142-51. Ter Arkh. 1981. PMID: 6457407 Review. Russian. No abstract available.
-
Management of early inflammatory arthritis. Intervention with immunomodulatory agents: new pharmacological developments.Baillieres Clin Rheumatol. 1992 Jun;6(2):455-84. doi: 10.1016/s0950-3579(05)80185-2. Baillieres Clin Rheumatol. 1992. PMID: 1525848 Review. No abstract available.
Cited by
-
Rectal administration of feprazone in healthy volunteers.Br J Clin Pharmacol. 1976 Apr;3(2):339-40. doi: 10.1111/j.1365-2125.1976.tb00616.x. Br J Clin Pharmacol. 1976. PMID: 973970 Free PMC article. Clinical Trial. No abstract available.
-
An analysis of the gastro-intestinal side-effects of non-steroidal anti-inflammatory drugs, with particular reference to comparative studies in man and laboratory species.Rheumatol Int. 1982;2(1):1-10. doi: 10.1007/BF00541263. Rheumatol Int. 1982. PMID: 7178760
-
Incidence of gastric side effects in controlled trials with unbranded aspirin and with various long-acting aspirin preparations.Ann Rheum Dis. 1978 Aug;37(4):389. doi: 10.1136/ard.37.4.389-a. Ann Rheum Dis. 1978. PMID: 686874 Free PMC article. No abstract available.