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. 2000 Aug;19(4):472S-477S.
doi: 10.1080/07315724.2000.10718950.

Influence of conjugated linoleic acid (CLA) on establishment and progression of atherosclerosis in rabbits

D Kritchevsky  1 , S A Tepper, S Wright, P Tso, S K Czarnecki
Affiliations

Influence of conjugated linoleic acid (CLA) on establishment and progression of atherosclerosis in rabbits

D Kritchevsky et al. J Am Coll Nutr. 2000 Aug.

Abstract

Objective: To determine effects of conjugated linoleic acid (CLA) on establishment and progression of experimentally-induced atherosclerosis in rabbits.

Methods: For establishment of atherosclerosis, New Zealand White rabbits were fed a semipurified diet containing 0.1% to 0.2% cholesterol for 90 days. Some groups were fed diet and CLA. For effects on progression of atherosclerosis, rabbits with established atherosclerosis were fed a semipurified diet +/- CLA for 90 days.

Results: At dietary levels as low as 0.1%, CLA inhibited atherogenesis. At dietary levels of 1%, CLA caused substantial (30%) regression of established atherosclerosis. This is the first example of substantial regression of atherosclerosis being caused by diet alone.

Conclusion: Dietary CLA is an effective inhibitor of atherogenesis and also causes regression of established atherosclerosis.

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