Review
doi: 10.1038/35021228.
Toll-like receptors in the induction of the innate immune response
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- PMID: 10963608
- DOI: 10.1038/35021228
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Review
Toll-like receptors in the induction of the innate immune response
Nature.
.
Abstract
The innate immune response is the first line of defence against infectious disease. The principal challenge for the host is to detect the pathogen and mount a rapid defensive response. A group of proteins that comprise the Toll or Toll-like family of receptors perform this role in vertebrate and invertebrate organisms. This reflects a remarkable conservation of function and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights into host defence.
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