Review
doi: 10.1038/35021233.
CD1-restricted T-cell responses and microbial infection
Affiliations
- PMID: 10963609
- DOI: 10.1038/35021233
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Review
CD1-restricted T-cell responses and microbial infection
Nature.
.
Abstract
CD1, a conserved family of major histocompatibility (MHC)-like glycoproteins in mammals, specializes in capturing lipid rather than peptide antigen for presentation to T lymphocytes. The principles and mechanisms of this newly discovered immune strategy differ markedly from those governing classical MHC-peptide presentation. They might be exploited for the design of new lipid-based microbial vaccines and adjuvants.
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