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. 2000 Sep 1;289(5484):1567-9.
doi: 10.1126/science.289.5484.1567.

Extension of life-span with superoxide dismutase/catalase mimetics

S Melov  1 , J Ravenscroft, S Malik, M S Gill, D W Walker, P E Clayton, D C Wallace, B Malfroy, S R Doctrow, G J Lithgow
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Extension of life-span with superoxide dismutase/catalase mimetics

S Melov et al. Science. .

Abstract

We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by pharmacological intervention.

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  • A long journey to reproducible results.
    Lithgow GJ, Driscoll M, Phillips P. Lithgow GJ, et al. Nature. 2017 Aug 22;548(7668):387-388. doi: 10.1038/548387a. Nature. 2017. PMID: 28836615 Free PMC article. No abstract available.

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