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. 1979 Apr;10(1-2):141-9.
doi: 10.1016/0047-6374(79)90077-0.

Transfer RNA in aging Drosophila: II. Isoacceptor patterns

H A Hosbach, E Kubli

Transfer RNA in aging Drosophila: II. Isoacceptor patterns

H A Hosbach et al. Mech Ageing Dev. 1979 Apr.

Abstract

Transfer RNA and aminoacyl-tRNA synthetases have been isolated from 5 and 35 day old Drosophila melanogaster males. The isoacceptor pattern of the following tRNAs is not changed irrespective of the source of the tRNA and amino-acylating enzymes: tRNAAla, tRNALeu, tRNAMet, and tRNASer. However, the Q base containing tRNAAsp, tRNAAsN, tRNAHis, and tRNATyr show dramatic changes in their isoacceptor patterns during the aging process. This probably reflects a change in the activity of a tRNA modifying enzyme. These findings are discussed in relation to Strehler's theory of aging and development.

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