doi: 10.1016/0014-2999(75)90305-2.
alpha-Methylnoradrenaline induced hypotension and bradycardia after administration into the area of the nucleus tractus solitarii
- PMID: 1097260
- DOI: 10.1016/0014-2999(75)90305-2
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alpha-Methylnoradrenaline induced hypotension and bradycardia after administration into the area of the nucleus tractus solitarii
Eur J Pharmacol.
1975 Jun-Jul.
Abstract
Bilateral injections of alpha-methylnoradrenaline into the area of the nucleus tractus solitarii of the brain stem caused a dose-dependent decrease of systemic arterial blood pressure and heart rate of anesthetized rats. The effects were prevented and even reversed by a preceding injection of the alpha-adrenoceptor blocking agent phentolamine. Pressor doses of angiotensin II and of arginine-vasopressin at the same site failed to drcrease blood pressure and heart rate.
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