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. 2000 Sep;25(9):419-21.
doi: 10.1016/s0968-0004(00)01631-5.

On the conservation of protein sequences in evolution

B Kisters-Woike  1 , C Vangierdegom, B Müller-Hill
Affiliations

On the conservation of protein sequences in evolution

B Kisters-Woike et al. Trends Biochem Sci. 2000 Sep.

Abstract

The amino acid sequences of enzymes like alcohol dehydrogenase and glyceraldehyde-3-phosphate dehydrogenase are strongly conserved across all phyla. We suggest that the amino acid conservation of such enzymes might be a result of the fact that they function as part of a multi-enzyme complex. The specific interactions between the proteins involved would hinder evolutionary change of their surfaces.

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