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. 2000 Sep;1(3):214-20.
doi: 10.1038/79749.

BCL-6 regulates chemokine gene transcription in macrophages

L M Toney  1 , G Cattoretti, J A Graf, T Merghoub, P P Pandolfi, R Dalla-Favera, B H Ye, A L Dent
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BCL-6 regulates chemokine gene transcription in macrophages

L M Toney et al. Nat Immunol. 2000 Sep.

Abstract

The transcriptional repressor protein BCL-6, implicated in the pathogenesis of B cell lymphoma, regulates lymphocyte differentiation and inflammation. We investigated the mechanism for the T helper cell subset 2 (TH2)-type inflammation that occurs in BCL-6-/- mice. Using chimeric mice we found that the TH2-type inflammation is dependent upon nonlymphoid cells. We identified three chemokines, MCP-1, MCP-3 and MRP-1, which are negatively regulated by BCL-6 in macrophages. Promoter analysis revealed that BCL-6 is a potent repressor of MCP-1 transcription. Our results provide a mechanism for the regulation of TH2-type inflammation by BCL-6 and link TH2 differentiation to innate immunity.

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