Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2000 Sep;7(5):842-4.
doi: 10.1128/CDLI.7.5.842-844.2000.

Prevalence of CagA and VacA antibodies in children with Helicobacter pylori-associated peptic ulcer compared to prevalence in pediatric patients with active or nonactive chronic gastritis

T Alarcón  1 , M J Martínez, P Urruzuno, M L Cilleruelo, D Madruga, M Sebastian, D Domingo, J C Sanz, M López-Brea
Affiliations
Comparative Study

Prevalence of CagA and VacA antibodies in children with Helicobacter pylori-associated peptic ulcer compared to prevalence in pediatric patients with active or nonactive chronic gastritis

T Alarcón et al. Clin Diagn Lab Immunol. 2000 Sep.

Abstract

VacA and CagA serological responses were detected in pediatric patients: 44 and 56%, respectively, in peptic ulcer (PU) patients, 33.3 and 44.4% in active chronic gastritis (ACG) patients, and 23.2 and 39.2% in non-ACG patients. Higher seroprevalence to CagA+VacA and to CagA+VacA+35-kDa antigen was found among PU patients. However, a low level of sensitivity and specificity was found for indirect detection of PU patients.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Atherton J, Covacci A. Pathogenic properties of Helicobacter pylori. Curr Opin Gastroenterol. 1997;13:20–24.
    1. Aucher P, Petit M L, Mannant P R, Pezennec L, Babin P, Fauchere J L. Use of immunoblot assay to define serum antibody patterns associated with Helicobacter pylori infection and with H. pylori-related ulcers. J Clin Microbiol. 1998;36:931–936. - PMC - PubMed
    1. Camorlinga-Ponce M, Torres J, Pérez-Pérez G, Leal-Herrera Y, Gonzalez-Ortiz B, Madrazo de la Garza A, Gómez A, Muñoz O. Validation of a serologic test for the diagnosis of Helicobacter pylori infection and the immune response to urease and CagA in children. Am J Gastroenterol. 1998;93:1264–1270. - PubMed
    1. Censini S, Lange C, Xiang Z Y, Crabtree J E, Ghiara P, Borodovsky M, Rappuoli R, Covacci A. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci USA. 1996;93:14648–14653. - PMC - PubMed
    1. Domingo D, Alarcón T, Prieto N, Sánchez I, López-Brea M. cagA and vacA status of Spanish Helicobacter pylori clinical isolates. J Clin Microbiol. 1999;37:2113–2114. - PMC - PubMed

Publication types

MeSH terms

Substances