Genetic control of susceptibility to experimental allergic encephalomyelitis and the Ag-B locus of rats
- PMID: 1097514
Item in Clipboard
Genetic control of susceptibility to experimental allergic encephalomyelitis and the Ag-B locus of rats
J Immunol.
1975 Aug.
Abstract
Injection of guinea pig spinal cord with complete Freund's adjuvant induces EAE in Lewis (Ag-B1) and DA (Ag-B4) rats, but not in rats of the BN (Ag-B3) strain. When BN is crossed with Lewis, susceptibility is determined by a gene linked to the Ag-B histocompatibility locus, but a much more complex mode of inheritance is involved when BN and DA rats are crossed. Six inbred strains possessing the Ag-B1 histocompatibility allele have been found to be susceptible to EAE. Evidence for recombination between the Ag-B locus and the gene determining susceptibility to EAE has not yet been obtained.
Similar articles
-
Genetic control of the development of experimental allergic encephalomyelitis in rats. Separation of MHC and non-MHC gene effects.J Immunol. 1988 Sep 1;141(5):1489-94. J Immunol. 1988. PMID: 2457618
-
Allergic encephalomyelitis in the reputedly resistant Brown Norway strain of rats.J Immunol. 1975 Feb;114(2 Pt 1):597-601. J Immunol. 1975. PMID: 1120901
-
Association between susceptibility to experimental allergic encephalomyelitis and the major histocompatibility system in congenic rat strains.Clin Exp Immunol. 1978 Jun;32(3):429-34. Clin Exp Immunol. 1978. PMID: 99279 Free PMC article.
-
Linkage of severity of experimental allergic encephalomyelitis to the rat major histocompatibility locus.J Immunol. 1980 Apr;124(4):1815-20. J Immunol. 1980. PMID: 6767774
-
Transplantation and cutaneous genetics.J Invest Dermatol. 1973 Jun;60(6):509-15. doi: 10.1111/1523-1747.ep12703576. J Invest Dermatol. 1973. PMID: 4581948 Review. No abstract available.
Cited by
-
Successful immunization against experimental allergic encephalomyelitis with myelin basic protein-sensitized allogeneic lymphocytes.Neurochem Res. 1981 Jun;6(6):699-718. doi: 10.1007/BF00963886. Neurochem Res. 1981. PMID: 6168929
-
Nitric oxide contributes to resistance of the Brown Norway rat to experimental autoimmune encephalomyelitis.Am J Pathol. 2005 Jan;166(1):147-57. doi: 10.1016/S0002-9440(10)62240-7. Am J Pathol. 2005. PMID: 15632008 Free PMC article.
-
Genetic control of susceptibility to autologous immune complex glomerulonephritis in inbred rat strains.Clin Exp Immunol. 1978 Jul;33(1):88-94. Clin Exp Immunol. 1978. PMID: 152175 Free PMC article.
-
Limiting-dilution analysis of the frequency of myelin basic protein-reactive T cells in Lewis, PVG/c and BN rats. Implication for susceptibility to autoimmune encephalomyelitis.Immunology. 1990 Feb;69(2):215-21. Immunology. 1990. PMID: 1689693 Free PMC article.
-
Genetic resistance to the induction of experimental allergic encephalomyelitis in Lewis rats. I. Genetic analysis of an apparent mutant strain with phenotypic resistance to experimental allergic encephalomyelitis.J Exp Med. 1981 Jan 1;153(1):61-74. doi: 10.1084/jem.153.1.61. J Exp Med. 1981. PMID: 6161206 Free PMC article.