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. 1975 Jun;18(6):727-30.
doi: 10.1021/jm00240a023.

7-N-amidinocephalosporins

J Altman, E Karoly, N Maoz

7-N-amidinocephalosporins

J Altman et al. J Med Chem. 1975 Jun.

Abstract

7-Aminocephalosporanic acid tert-butyl ester reacts quantitatively at--20 degrees with iminium chlorides to give amidino derivatives. Removal of the tert-butyl protecting group with trifluoroacetic acid and treatment with 1 equiv of triethylamine yield the corresponding zwitterions. These compounds were less active than their penicillin analogs.

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