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. 1975 Mar 1;53(5):205-8.
doi: 10.1007/BF01468808.

Liver cirrhosis: immunofluorescence and biochemical studies demonstrate two types of collagen

S Gay, P P Fietzek, K Remberger, M Eder, K Kühn

Liver cirrhosis: immunofluorescence and biochemical studies demonstrate two types of collagen

S Gay et al. Klin Wochenschr. .

Abstract

Pepsin solubilization of small and large noduled liver cirrhosis yielded two types of collagen (precipitated at 1.7 and 2.5 M NaCl concentrations) as demonstrated by electronmicroscopy. The 1.7 M NaCl precipitate was identified as type III collagen using an immunofluorescence technique. The 2.5 M NaCl precipitate appeared to be type I in the electronmicroscope. However, immunofluorescent and biochemical studies indicated that it was not type I but a type of collagen not yet described.

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