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Review
. 2000 Sep;2(5):378-85.
doi: 10.1007/s11886-000-0050-1.

Platelet activation in acute myocardial infarction and the rationale for combination therapy

I Conde-Pozzi  1 , N Kleiman
Affiliations
Review

Platelet activation in acute myocardial infarction and the rationale for combination therapy

I Conde-Pozzi et al. Curr Cardiol Rep. 2000 Sep.

Abstract

Current fibrinolytic regimens fail to fully restore coronary blood flow in slightly less than 50% of patients with acute myocardial infarction. Platelet activation and aggregation may be responsible for a large proportion of these therapeutic failures. Therefore, platelet inhibition may enhance thrombolysis. Experimental and early clinical evidence suggest that glycoprotein IIb/IIIa antagonists may enhance reperfusion when combined with reduced doses of thrombolytic agents. However, the clinical benefit of combination therapy will depend on the outcomes of a number large clinical trials that are currently being performed.

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