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. 2000 Aug;15 Suppl(Suppl):S27-8.
doi: 10.3346/jkms.2000.15.S.S27.

Serotonin and pancreatic duct function

S Naruse  1 , A Suzuki, H Ishiguro, M Kitagawa, S B Ko, T Yoshikawa, A Yamamoto, H Hamada, T Hayakawa
Affiliations

Serotonin and pancreatic duct function

S Naruse et al. J Korean Med Sci. 2000 Aug.

Abstract

1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.

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