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Review
. 2000 Aug;10(4):401-4.
doi: 10.1016/s0959-440x(00)00105-6.

Recent advances in structure-based rational drug design

P J Gane  1 , P M Dean
Affiliations
Review

Recent advances in structure-based rational drug design

P J Gane et al. Curr Opin Struct Biol. 2000 Aug.

Abstract

Two approaches to structure-based drug design, that is, the docking of known compounds into a target protein and molecular assembly in situ, are seen to be merging technologies. The need for structural information about drug-protein complexes is now fundamental for drug discovery.

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