[The influence of calcium channel blockers on the effects of anxiogenic preparations]
[Article in
Russian]
- PMID: 10983469
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[The influence of calcium channel blockers on the effects of anxiogenic preparations]
[Article in
Russian]
Patol Fiziol Eksp Ter.
2000 Jul-Sep.
Abstract
The effect of anxiogenic drugs (caffeine, pentilentetrazole, phenilethylamine, strophantine, BAY K 8644) on SHR mice' behavior was studied in the dark-light chamber test. All these drugs have diminished the number of transitions between the chambers. Pretreatment with verapamil, nifedipine, cinnarizine and fendilin have not altered the effect of relevant anxiogenic drugs. Diltiazem prevented the effect of stophantine. It is suggested that the lack of the effect of calcium channel blockers on the action of anxiogens is related to peculiarities of formation of anxiety in this test.
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