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Comparative Study
. 1975 Jul;130(1):53-6.
doi: 10.1016/0002-9610(75)90457-2.

Prolongation of pancreatic allograft survival by 5-fluorouracil

J Castellanos, G Manifacio, L Toledo-Pereyra, R C Lillehei, C H Shatney
Comparative Study

Prolongation of pancreatic allograft survival by 5-fluorouracil

J Castellanos et al. Am J Surg. 1975 Jul.

Abstract

Recipient survival in canine pancreatic allotransplantation was significantly prolonged when animals were treated with 5-fluorouracil in combination with low-dose azathioprine. Untreated dogs and those receiving only azathioprine survived for only short periods of time, and pancreatitis was frequently encountered. In contrast, animals treated with 5-fluorouracil were protected from pancreatitis and survived an average of almost three weeks.

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