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Review
. 2000 Oct;67(4):788-92.
doi: 10.1086/303098. Epub 2000 Sep 8.

Genomic sequence, splicing, and gene annotation

S M Mount  1
Affiliations
Review

Genomic sequence, splicing, and gene annotation

S M Mount. Am J Hum Genet. 2000 Oct.
No abstract available

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Figures

Figure 1
Figure 1
Small internal exons and resplicing. This schematic figure indicates the pathway of resplicing demonstrated for the Drosophila Ubx locus (Hatton et al. 1998). The thicker vertical line indicates a resplicing site, which does not contribute any nucleotides to the final mRNA product. The same pathway could be followed in the case of a microexon, in which case an arbitrarily small number of nucleotides would remain in the mRNA product. “Up. Exon” and “Down. Exon” denote the exons upstream and downstream of the resplicing site, respectively. In the case of Ubx, the sequence immediately downstream of the resplicing site is an alternatively spliced exon (here designated “Alt. Exon"), but resplicing sites are not always accompanied by such alternatively spliced exons (J. Burnette and A. J. Lopez, personal communication).
See this image and copyright information in PMC

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References

Electronic-Database Information

    1. Computational Genefinding, http://www.cse.ucsc.edu/~haussler/genefindingpaper
    1. GadFly: Genome Annotation Database of Drosophila, http://www.fruitfly.org/annot/index.html
    1. GenBank, http://www.ncbi.nlm.nih.gov/ (for incorrect annotation of invected [accession number AE003825.1] and predicted protein sequence [accession numbers AAF58640 and CAA28885])
    1. Gene Annotation and Splice Site Selection, http://www.wam.umd.edu/~smount/Annotation.html
    1. Genome Annotation Assessment Project-GASP1, http://www.fruitfly.org/GASP1/index.html

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