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. 1975 Apr;25(4):571-6.

[Phalloidin antagonists. 2. Protective effect of disilybine in phalloidin poisoning of isolated hepatocytes]

[Article in German]
V E Petzinger, J Homann, M Frimmer
  • PMID: 1098677

[Phalloidin antagonists. 2. Protective effect of disilybine in phalloidin poisoning of isolated hepatocytes]

[Article in German]
V E Petzinger et al. Arzneimittelforschung. 1975 Apr.

Abstract

Phalloidin produces marked protrusions on the surface of isolated hepatocytes prepared from rat livers. This typical in-vitro effect of the mushroom toxin is prevented or inhibited by preincubation with disilybin. The antagonistic effect depends on the concentration of disilybin and might be caused by an inhibition of phalloidin binding.

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