Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2000 Sep 4;10(17):1897-9.
doi: 10.1016/s0960-894x(00)00372-3.

DNA triple helix stabilization by aminoglycoside antibiotics

D P Arya  1 , R L Coffee Jr
Affiliations

DNA triple helix stabilization by aminoglycoside antibiotics

D P Arya et al. Bioorg Med Chem Lett. .

Abstract

The stabilization of the poly(dA) x 2poly(dT) triple helix by neomycin is reported. Preliminary results indicate that neomycin stabilizes DNA triple helices and the double helical structures composed of poly(dA) x poly(dT) are virtually unaffected. This is the first report of the interaction of aminoglycoside antibiotics with DNA triple helices.

PubMed Disclaimer

Publication types

LinkOut - more resources