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Clinical Trial
. 1975 Aug;36(2):308-10.
doi: 10.1002/1097-0142(197508)36:2<308::aid-cncr2820360203>3.0.co;2-1.

Combined androgen and antimetabolite therapy of advanced female breast cancer. A report of the cooperative breast cancer group

I S Goldenberg, N Sedransk, H Volk, A Segaloff, R M Kelley, C R Haines
Clinical Trial

Combined androgen and antimetabolite therapy of advanced female breast cancer. A report of the cooperative breast cancer group

I S Goldenberg et al. Cancer. 1975 Aug.

Abstract

A clinical trial of androgen and antimetabolite therapy of advanced female breast cancer was conducted in 110 patients by the Cooperative Breast Cancer Group. An objective regression rate of 20% was achieved in women receiving oral testolactone, 6% in patients given intravenous fluorouracil alone, and 14% when the androgen and antimetabolite were administered together. This randomized trial according to the CBCG protocol did not produce the high regression rate noted previously in a nonrandomized, nonprotocol evaluation of these drugs.

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