Review
doi: 10.1016/s0966-842x(00)01816-3.
The chimpanzee and other non-human-primate models in HIV-1 vaccine research
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- PMID: 10989311
- DOI: 10.1016/s0966-842x(00)01816-3
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Review
The chimpanzee and other non-human-primate models in HIV-1 vaccine research
Trends Microbiol.
2000 Sep.
Free article
Abstract
Animal models are of great importance for the study of disease pathogenesis, particularly non-human-primate models of infectious diseases. The role of non-human primates in HIV-1 research is continually discussed and debated. Here, we examine three primate models: chimpanzee-HIV-1, rhesus macaque-simian immunodeficiency virus and rhesus macaque-SHIV, and discuss immunological similarities and differences, safety and monetary issues, and ethical concerns.
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