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Review
. 2000 Sep;8(9):426-31.
doi: 10.1016/s0966-842x(00)01816-3.

The chimpanzee and other non-human-primate models in HIV-1 vaccine research

B M Nath  1 , K E Schumann, J D Boyer
Affiliations
Free article
Review

The chimpanzee and other non-human-primate models in HIV-1 vaccine research

B M Nath et al. Trends Microbiol. 2000 Sep.
Free article

Abstract

Animal models are of great importance for the study of disease pathogenesis, particularly non-human-primate models of infectious diseases. The role of non-human primates in HIV-1 research is continually discussed and debated. Here, we examine three primate models: chimpanzee-HIV-1, rhesus macaque-simian immunodeficiency virus and rhesus macaque-SHIV, and discuss immunological similarities and differences, safety and monetary issues, and ethical concerns.

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