doi: 10.1002/chin.200047151.
New pyrazolo[3,4-b]pyrazines: synthesis and biological activity
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- PMID: 10989833
- DOI: 10.1002/chin.200047151
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New pyrazolo[3,4-b]pyrazines: synthesis and biological activity
Pharmazie.
2000 Aug.
Abstract
Some new pyrazolo[3,4-b]pyrazines and related heterocycles were synthesized and evaluated for their antifungal and antiparasitic activities. The key intermediate, 6-amino-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyrazine-5-carbonitrile (3) was obtained in a one-pot synthesis via the reaction of 5-amino-3-methyl-4-nitroso-1-phenylpyrazole 2 with malononitrile.
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