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Comment
. 2000 Sep;106(6):749-52.
doi: 10.1172/JCI11089.

Interactions between immune and bone cells: new insights with many remaining questions

J Lorenzo  1
Affiliations
Comment

Interactions between immune and bone cells: new insights with many remaining questions

J Lorenzo. J Clin Invest. 2000 Sep.
No abstract available

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Figures

Figure 1
Figure 1
Regulation of osteoclast formation. In normal physiology, osteoclast formation is regulated by production of membrane-bound RANK-L/OPG-L and soluble OPG in stromal/osteoblastic cells under the influence of stimulators of resorption. In inflammatory states, activated T lymphocytes produce both membrane-bound and soluble RANK-L/OPG-L, which stimulates RANK on osteoclast precursor cells and initiates their differentiation into osteoclasts. IL-1, TNF, and PGE2 may also directly affect osteoclast precursors or mature osteoclasts.
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