doi: 10.1016/s0960-9822(00)00680-1.
Glycoprotein degradation: do sugars hold the key?
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- PMID: 10996809
- DOI: 10.1016/s0960-9822(00)00680-1
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Glycoprotein degradation: do sugars hold the key?
Curr Biol.
.
Free article
Abstract
Secretory glycoproteins that fail to fold or assemble correctly are retained in the endoplasmic reticulum and eventually degraded. Recent evidence shows that trimming of their N-linked oligosaccharide chains plays a key role in targeting glycoproteins for destruction.
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