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Case Reports
. 2000 Apr-Jun;43(2):99-104.
doi: 10.1016/s0003-3995(00)01019-4.

Acute megakaryocytic leukaemia with acquired polysomy 21 and translocation t(1;21)

S Paulien  1 , M Busson-Le Coniat, R Berger
Affiliations
Case Reports

Acute megakaryocytic leukaemia with acquired polysomy 21 and translocation t(1;21)

S Paulien et al. Ann Genet. 2000 Apr-Jun.

Abstract

Cytogenetic study of a young child with acute megakaryocytic leukaemia (AML-M7) has shown a karyotype with 49-50 chromosomes with one and two acquired extra chromosomes 21. Fluorescence in situ hybridization detected a minor clone with translocation t(1;21) and loss of a part of chromosome band 1p36. Trisomy and polysomy 21 are not uncommon in AML-M7. A more systematic search for chromosome 21 rearrangements in AML-M7 using FISH techniques is proposed.

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