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. 2000 Sep 18;10(18):2047-50.
doi: 10.1016/s0960-894x(00)00270-5.

Discovery of a new class of p38 kinase inhibitors

J Dumas  1 , R Sibley, B Riedl, M K Monahan, W Lee, T B Lowinger, A M Redman, J S Johnson, J Kingery-Wood, W J Scott, R A Smith, M Bobko, R Schoenleber, G E Ranges, T J Housley, A Bhargava, S M Wilhelm, A Shrikhande
Affiliations

Discovery of a new class of p38 kinase inhibitors

J Dumas et al. Bioorg Med Chem Lett. .

Abstract

The MAP kinase p38 has been implicated in cytokine signaling, and its inhibitors are potentially useful for the treatment of arthritis and osteoporosis. Novel small-molecule inhibitors of p38 kinase were derived from a combinatorial chemistry effort and exhibit activity in the nanomolar range. Very steep structure-activity relationships are observed within this class.

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