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Review
. 1975 Oct;36(4):1258-68.
doi: 10.1002/1097-0142(197510)36:4<1258::aid-cncr2820360411>3.0.co;2-6.

Clinical comparison of the nitrosoureas

T H Wasserman, M Slavik, S K Carter
Review

Clinical comparison of the nitrosoureas

T H Wasserman et al. Cancer. 1975 Oct.

Abstract

The nitrosourea group of antitumor agents was developed by the Division of Cancer Treatment of the National Cancer Institute. Three nitrosoureas (BCNU, CCNU, MeCCNU) have undergone extensive clinical trials, and two of them (BCNU, CCNU) will soon become commercially available. This paper briefly considers the preclinical development of the nitrosoureas and provides an overview and comparison of the extensive clinical data. Information is given regarding any clinical differences. We discuss general conclusions drawn from the nitrosourea development.

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