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Review
. 2000 Oct;22(7):700-13.
doi: 10.1002/1097-0347(200010)22:7<700::aid-hed10>3.0.co;2-h.

Ischemia/reperfusion injury in microvascular surgery

W R Carroll  1 , R M Esclamado
Affiliations
Review

Ischemia/reperfusion injury in microvascular surgery

W R Carroll et al. Head Neck. 2000 Oct.

Abstract

Ischemia/reperfusion injury is often the final and irreversible factor causing flap failure in microvascular surgery for head and neck defects. This paper begins with a detailed review of flap physiology and ischemia/reperfusion injury at the cellular level. Subsequently, the pharmacotherapeutic agents used clinically and experimentally to avoid or reverse ischemia/reperfusion injury are discussed. The goal of this review is to provide a framework for understanding the expanding body of literature relevant to ischemia/reperfusion injury in microvascular surgery.

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