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. 1975 Sep;12(3):602-5.
doi: 10.1128/iai.12.3.602-605.1975.

Hepatitis B antigens in serum and liver of chimpanzees acutely infected with hepatitis B virus

K R Berquist, J M Peterson, B L Murphy, J W Ebert, J E Maynard, R H Purcell

Hepatitis B antigens in serum and liver of chimpanzees acutely infected with hepatitis B virus

K R Berquist et al. Infect Immun. 1975 Sep.

Abstract

We report the temporal patterns of various immunohistological and serological parameters of acute self-limited hepatitis B virus infection of two chimpanzees, and we provide evidence that the synthesis of hepatitis B core antigen precedes that of hepatitis B surface antigen. Our data suggest that existence of a biphasic hepatitis B virus infection involving a hematogenous reinfection of the liver and indicate that recruitment of liver cells to produce hepatitis B virus may occur in a pattern consistent with a replicative cycle of about 8 days.

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