Biological and clinical review of stromal tumors in the gastrointestinal tract
- PMID: 11005253
- DOI: 10.14670/HH-15.1293
Biological and clinical review of stromal tumors in the gastrointestinal tract
Abstract
Submucosal tumors of the gastrointestinal tract (GI tract) mainly consist of gastrointestinal mesenchymal tumors (GIMTs) that are distributed in the GI tract from the esophagus through the rectum. GIMTs include myogenic tumors, neurogenic tumors and gastrointestinal stromal tumors (GISTs). The term "GIST" is now preferentially used for the tumors that express CD34 and KIT. GIMTs are composed of spindle or epithelioid cells, and 20% to 30% show malignant behavior, including peritoneal dissemination and hematogenous metastasis. KIT expression and mutations in the c-kit gene are found only in GISTs, but not in myogenic or neurogenic tumors. Mutation in the c-kit gene is associated with aggressive features and poor prognosis, and malignant GISTs frequently have mutations in the c-kit gene. The clinicopathological features of GISTs with or without c-kit mutations are markedly different. Therefore, GIMTs may be divided into four major categories based on histochemical and genetic data: myogenic tumors; neurogenic tumors; GISTs with c-kit mutation; and GISTs without c-kit mutation. The origin of GISTs is not fully understood. However, phenotypical resemblance to the interstitial cells of Cajal (ICCs) and gain-of-function mutations in the c-kit gene may suggest origin from ICCs and/or multipotential mesenchymal cells that differentiate into ICCs.
Similar articles
-
Pathology and diagnostic criteria of gastrointestinal stromal tumors (GISTs): a review.Eur J Cancer. 2002 Sep;38 Suppl 5:S39-51. doi: 10.1016/s0959-8049(02)80602-5. Eur J Cancer. 2002. PMID: 12528772 Review.
-
Clinicopathological features of gastric stromal tumors.J Exp Clin Cancer Res. 2000 Dec;19(4):417-25. J Exp Clin Cancer Res. 2000. PMID: 11277317
-
Gastrointestinal stromal tumors--definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis.Virchows Arch. 2001 Jan;438(1):1-12. doi: 10.1007/s004280000338. Virchows Arch. 2001. PMID: 11213830 Review.
-
Gastrointestinal stromal tumors: recent advances in understanding of their biology.Hum Pathol. 1999 Oct;30(10):1213-20. doi: 10.1016/s0046-8177(99)90040-0. Hum Pathol. 1999. PMID: 10534170 Review.
-
Mutations in exon 11 of the c-kit gene in a myogenic tumor and a neurogenic tumor as well as in gastrointestinal stromal tumors. Utility of c-kit mutation as a prognostic biomarker for gastrointestinal mesenchymal tumor.Dig Surg. 2003;20(3):183-91. doi: 10.1159/000070384. Dig Surg. 2003. PMID: 12759497
Cited by
-
KIT gene mutations in gastrointestinal stromal tumors: more complex than previously recognized?Am J Pathol. 2002 Aug;161(2):737-8; author reply 738-9. doi: 10.1016/S0002-9440(10)64229-0. Am J Pathol. 2002. PMID: 12163398 Free PMC article. No abstract available.
-
Laparoscopic distal gastrectomy for synchronous adenocarcinoma, diffuse large B cell lymphoma and gastrointestinal stromal tumor in the stomach: a case report.Surg Case Rep. 2022 May 8;8(1):89. doi: 10.1186/s40792-022-01446-1. Surg Case Rep. 2022. PMID: 35526194 Free PMC article.
-
Clinicopathological characteristics of gastrointestinal schwannomas: A retrospective analysis of 78 cases.Front Oncol. 2022 Dec 13;12:1003895. doi: 10.3389/fonc.2022.1003895. eCollection 2022. Front Oncol. 2022. PMID: 36582806 Free PMC article.
-
Distribution and possible role of PDGF-AA and PDGFR-alpha in the gastrointestinal tract of adult guinea pigs.Virchows Arch. 2010 Sep;457(3):381-8. doi: 10.1007/s00428-010-0946-0. Epub 2010 Jul 15. Virchows Arch. 2010. PMID: 20632033
-
Gastric schwannoma: a rare find.J Gastrointest Surg. 2013 Dec;17(12):2179-81. doi: 10.1007/s11605-013-2387-y. Epub 2013 Oct 22. J Gastrointest Surg. 2013. PMID: 24146341 No abstract available.