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Comment
. 2000 Sep 26;97(20):10673-5.
doi: 10.1073/pnas.97.20.10673.

Glycosylphosphatidylinositol biosynthesis validated as a drug target for African sleeping sickness

M A Ferguson  1
Affiliations
Comment

Glycosylphosphatidylinositol biosynthesis validated as a drug target for African sleeping sickness

M A Ferguson. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
The major surface molecules of T. brucei bloodstream and procyclic forms. The cartoons represent 20 nm × 20 nm portions of plasma membrane. The blue components of the VSGs represent the two GPI anchors that attach the VSG dimers to the membrane. The mature GPI anchors of the procyclins have very complex side chains and some procyclins contain small N-linked oligosaccharides beyond the polyanionic rod domain, as shown here.
Figure 2
Figure 2
The GPI biosynthetic pathways of T. brucei and mammalian cells. This is a consensus view based on the work of many groups, reviewed in refs. and . (A) The shaded area represents the pathway in T. brucei procyclic cells and the nonshaded area represents the additional fatty acid remodeling steps and attachment to VSG unique to T. brucei bloodstream forms. (A and B) The location of the MT-III enzyme, encoded by the TbGPI10 and PIG-B genes in the parasite (A) and mammalian (B) cells, respectively, is indicated in red.
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Comment on

References

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