Review
doi: 10.1016/s1367-5931(00)00130-7.
Cyclooxygenase mechanisms
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- PMID: 11006543
- DOI: 10.1016/s1367-5931(00)00130-7
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Review
Cyclooxygenase mechanisms
Curr Opin Chem Biol.
2000 Oct.
Abstract
Several advances have occurred in the past year in our understanding of cyclooxygenase catalysis. The role of specific heme oxidation states in the formation of catalytically competent tyrosyl radicals has been defined; the identity of physiological hydroperoxide activators has been established; and the participation of individual amino acids in substrate binding and oxygenation has been elucidated.
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