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Review
. 2000 Oct;4(5):573-80.
doi: 10.1016/s1367-5931(00)00135-6.

Glycosidase mechanisms

C S Rye  1 , S G Withers
Affiliations
Review

Glycosidase mechanisms

C S Rye et al. Curr Opin Chem Biol. 2000 Oct.

Abstract

Insights into glycosidase mechanisms have come from X-ray crystallographic studies on complexes with substrate analogs and inhibitors, representing all the intermediate species along the reaction coordinate. Site-directed mutagenesis continues to play a significant role in understanding mechanisms, but is also proving important in generating glycosidases of modified mechanism or specificity.

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