doi: 10.1016/s0014-5793(00)02029-9.
Cleavage of yeast tRNAPhe with complementary oligonucleotide conjugated to a small ribonuclease mimic
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- PMID: 11007978
- DOI: 10.1016/s0014-5793(00)02029-9
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Cleavage of yeast tRNAPhe with complementary oligonucleotide conjugated to a small ribonuclease mimic
FEBS Lett.
.
Free article
Abstract
An oligonucleotide conjugate bearing a chemical construct mimicking the catalytic center of ribonuclease A has been designed and studied. The conjugate efficiently cleaves yeast tRNAPhe at a single site adjacent to the target complementary sequence.
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