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. 2000 Jul;26(7):505-11.

[Biologically active fragment of the differentiation factor from HL-60 cell line. Identification and properties]

[Article in Russian]
I A Kostanian  1 , M V Astapova, E V Navolotskaia, T N Lepikhova, S M Dranitsyna, G B Telegin, I L Rodionov, L K Baĭdakova, Iu A Zolotarev, I M Molotkovskaia, V M Lipkin
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  • PMID: 11008640

[Biologically active fragment of the differentiation factor from HL-60 cell line. Identification and properties]

[Article in Russian]
I A Kostanian et al. Bioorg Khim. 2000 Jul.

Abstract

Six-membered peptide fragment TGENHR (HLDF-6) was identified in the HL-60 cell culture of human promyelocyte leukemia treated with retinoic acid when studying the differentiation factor HLDF of this cell line. HLDF-6 retains the ability of the full-size factor to induce the differentiation and arrest the proliferation of the starting HL-60 cells. It was shown that the synthetic peptide HLDF-6 has no specific receptors on the surface of the HL-60 cells but can affect the binding of interleukin IL-1 beta, a cytokine involved in proliferation, to the cell surface. It was found on a model of transplantable NSO myeloma that HLDF-6 has an antitumor activity.

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