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Review
. 2000 Oct;122(1):1-9.
doi: 10.1046/j.1365-2249.2000.01314.x.

Chronic granulomatous disease

D Goldblatt  1 , A J Thrasher
Affiliations
Review

Chronic granulomatous disease

D Goldblatt et al. Clin Exp Immunol. 2000 Oct.
No abstract available

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Figures

Fig. 1
Fig. 1
Schematic representation of the active NAPDH–oxidase complex. The flavocytochrome b558 consists of two components, gp91phox and p22phox, which reside in the membrane as a heterodimer. On activation of the cell, a complex of cytosolic components (see text) assembles at the membrane and induces electron transport from NADPH to molecular oxygen via flavin adenine dinucleotide (FAD) and haem groups. gp91phox has also recently been shown to act as a voltage-gated H + channel which could participate in charge compensation. Termination of activity may be regulated by the GTPase, p21rac.
See this image and copyright information in PMC

References

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