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. 1975 Jul;72(7):2649-52.
doi: 10.1073/pnas.72.7.2649.

Release of (oligo) peptidyl-tRNA from ribosomes by erythromycin A

T Otaka, A Kaji

Release of (oligo) peptidyl-tRNA from ribosomes by erythromycin A

T Otaka et al. Proc Natl Acad Sci U S A. 1975 Jul.

Abstract

Erythromycin A released peptidyl-tRNA in the in vitro polypeptide synthesis system with bacterial components programmed by synthetic polynucleotide. This is consistent with our hypothesis that erythromycin A inhibits translocation by preventing proper situation of oligopeptidyl-tRNA in the donor (D) site on ribosomes.

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References

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