[Suppression of interferon synthesis during the "graft-versus-host" reaction in F1(CBAXC57BL/6) mice]
[Article in
Russian]
- PMID: 11014
Item in Clipboard
[Suppression of interferon synthesis during the "graft-versus-host" reaction in F1(CBAXC57BL/6) mice]
[Article in
Russian]
Biull Eksp Biol Med.
1976 Sep.
Abstract
The development of the graft-versus-host reaction (GVHR) in the F1(1CBA X C57BL/6 hybrid mice after the transplantation of spleen cells from the C57BL/6 parent donor resulted in a strong inhibition of the serum interferon production induced by the intraperitoneal injection of the Newcastle disease virus. In vitro with the mouse bone marrow cells during the development of the GVHR the interferon response was first reduced and then disappeared completely. The described phenomenon could therefore serve as an index of the development of the GVHR.
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