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Review
. 2000 Oct;7(10):855-61.
doi: 10.1038/79603.

Approaching translation at atomic resolution

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Review

Approaching translation at atomic resolution

J D Puglisi et al. Nat Struct Biol. 2000 Oct.

Abstract

Atomic resolution structures of 50S and 30S ribosomal particles have recently been solved by X-ray diffraction. These ribosomal structures show often unusual folds of ribosomal RNAs and proteins, and provide molecular explanations for fundamental aspects of translation. In the 50S structure, the active site for peptide bond formation was localized and found to consist of RNA. The ribosome is thus a ribozyme. In the 30S structures, tRNA binding sites were located, and molecular mechanisms for ribosomal fidelity were proposed. The 30S subunit particle has three globular domains, and relative movements of these domains may be required for translocation of the ribosome during protein synthesis. The structures are consistent with and rationalize decades of biochemical analysis of translation and usher in a molecular age in understanding the ribosome.

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  • Picture story. Getting started.
    Feng HP. Feng HP. Nat Struct Biol. 2001 Feb;8(2):109. doi: 10.1038/84085. Nat Struct Biol. 2001. PMID: 11175895 No abstract available.

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