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. 2000 Sep 7;118(5):148-53.
doi: 10.1590/s1516-31802000000500007.

Evolution of nutritional status of infants infected with the human immunodeficiency virus

V A Leandro-Merhi  1 , M M Vilela, M N Silva, F A Lopez, A d Barros Filho
Affiliations

Evolution of nutritional status of infants infected with the human immunodeficiency virus

V A Leandro-Merhi et al. Sao Paulo Med J. .

Abstract
in English, Portuguese

Context: There are today only a limited number of studies defining growth parameters and nutritional status for HIV children.

Objective: To study the nutritional status of infants infected with the human immunodeficiency virus.

Type of study: Longitudinal study.

Setting: Department of Pediatrics, Faculty of Medical Sciences, UNICAMP, Campinas, Brazil.

Participants: One hundred and twenty-four children born to HIV infected mothers were evaluated from birth until the age of two years. They were subdivided into two groups: 71 infected children and 53 non-infected children.

Main measurements: Growth was evaluated in both groups by comparing Z-scores for weight/age (w/a), length/age (H/a) and weight/length (w/H) (using the NCHS curves as reference).

Results: The Z-score analyses showed that there was a significant difference between the two groups for all the variables studied, except for the H/a value at 3 months of age and the W/H value at 21 months of age, which showed P > 0.05.

Conclusions: The growth of infected infants was observed to be severely affected in comparison with that of seroreversed infants in the same age groups. Although clinical manifestations may take time to appear, the onset of growth changes begin soon after birth.

CONTEXTO:: Atualmente há estudos limitados que definem parâmetros de crescimento e estado nutricional em crianças com HIV.

OBJETIVO:: Estudar o estado nutricional de crianças infectadas com o vírus da imunodeficiência humana.

TIPO DE ESTUDO:: Estudo longitudinal.

LOCAL:: Serviço de imunodeficiência pediátrica da Universidade Estadual de Campinas, Campinas, Brasil.

PARTICIPANTES:: 124 crianças nascidas de mulheres infectadas com o HIV foram avaliadas desde o nascimento até dois anos de idade. Elas foram subdivididas em dois grupos: 71 crianças infectadas e 53 crianças não-infectadas.

PROCEDIMENTOS:: A avaliação do estado nutricional foi realizada pela comparação do Z-score para peso/idade(P/I),altura/idade(A/I) e peso/altura(P/A),usando as curvas do NCHS como referência. Para a comparação do Z-score foram utilizados os testes T de Student e U de Mann-Whitney. Os testes foram conduzidos ao nível de significância=5%.

RESULTADOS:: A análise do Z-score revelou que houve evidência de diferença entre os dois grupos, para todas as variáveis estudadas, exceto o índice de A/I aos 3 meses e P/A aos 21 meses.

CONCLUSÕES:: O estado nutricional das crianças infectadas foi grave-mente afetado em comparação com as crianças sororreversoras no mesmo grupo de idade. Embora as manifestações clínicas possam demorar a aparecer, as alterações no crescimento surgem logo após o nascimento.

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Conflict of interest statement

Conflict of interest: Not declared

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