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. 2000 Oct 6;290(5489):142-4.
doi: 10.1126/science.290.5489.142.

A calmodulin-related protein that suppresses posttranscriptional gene silencing in plants

R Anandalakshmi  1 , R Marathe, X Ge, J M Herr Jr, C Mau, A Mallory, G Pruss, L Bowman, V B Vance
Affiliations

A calmodulin-related protein that suppresses posttranscriptional gene silencing in plants

R Anandalakshmi et al. Science. .

Abstract

Posttranscriptional gene silencing (PTGS) is an ancient eukaryotic regulatory mechanism in which a particular RNA sequence is targeted and destroyed. The helper component-proteinase (HC-Pro) of plant potyviruses suppresses PTGS in plants. Using a yeast two-hybrid system, we identified a calmodulin-related protein (termed rgs-CaM) that interacts with HC-Pro. Here we report that rgs-CaM, like HC-Pro itself, suppresses gene silencing. Our work is the first report identifying a cellular suppressor of PTGS.

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