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Review
. 2000 Oct 7;321(7265):886-9.
doi: 10.1136/bmj.321.7265.886.

ABC of colorectal cancer. Molecular basis for risk factors

R G Hardy, S J Meltzer, J A Jankowski
Review

ABC of colorectal cancer. Molecular basis for risk factors

R G Hardy et al. BMJ. .
No abstract available

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Figures

Figure
Figure
Proposed adenoma to carcinoma sequence in colorectal cancer. Adenomatous polyposis coli (APC) gene mutations and hypermethylation occur early, followed by k ras mutations. Deleted in colon cancer (DCC) and p53 gene mutations occur later in the sequence, although the exact order may vary
Figure
Figure
Key molecular events in colorectal premalignancy: comparisons between the adenoma carcinoma sequence and ulcerative colitis associated neoplasia
Figure
Figure
Downregulation of E cadherin (arrowed) within colonic adenoma. Normal membranous E cadherin staining (brown) is seen in non-dysplastic crypts in the right of the picture
See this image and copyright information in PMC

MeSH terms