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Comparative Study
. 2000 Oct;154(4):473-6.
doi: 10.1667/0033-7587(2000)154[0473:htftmg]2.0.co;2.

Human TP53 from the malignant glioma-derived cell lines M059J and M059K has a cancer-associated mutation in exon 8

C W Anderson  1 , M J Allalunis-Turner
Affiliations
Comparative Study

Human TP53 from the malignant glioma-derived cell lines M059J and M059K has a cancer-associated mutation in exon 8

C W Anderson et al. Radiat Res. 2000 Oct.

Abstract

The protein coding segment of the TP53 genes from the glioma-derived cell lines M059J and M059K was sequenced. The sequences from both cell lines were identical over 5039 bp, including the gene segment containing exons 2 through 9, exon 10, and the proximal segment of exon 11. In both cells, the first nucleotide of codon 286 (GAA, Glu) is changed to an A (AAA, Lys). Comparison with the same TP53 segment from the A549 human lung carcinoma cell line revealed several differences in intron sequence.

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Comment in

  • Wild-type sequence of TP53, intron 7.
    Eicheler W, Baumann M. Eicheler W, et al. Radiat Res. 2001 Apr;155(4):641. doi: 10.1667/0033-7587(2001)155[0641:wtsoti]2.0.co;2. Radiat Res. 2001. PMID: 12931731 No abstract available.

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