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Review
. 2000 Nov;67(5):1055-61.
doi: 10.1016/S0002-9297(07)62935-8. Epub 2000 Oct 6.

Messages through bottlenecks: on the combined use of slow and fast evolving polymorphic markers on the human Y chromosome

P de Knijff
Review

Messages through bottlenecks: on the combined use of slow and fast evolving polymorphic markers on the human Y chromosome

P de Knijff. Am J Hum Genet. 2000 Nov.
No abstract available

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Figures

Figure 1
Figure 1
The bottleneck model. It is assumed that no strange Y lineages were introduced into our population by means of migration and that each UME occurred only once. In our example, we have genotypic information from three UMEs and from a number of STRs. A, From sequence information obtained from nonhuman primates, we know the ancestral status of each of these UMEs, here designated as “0.” Subsequently, the derived state of each UME is designated as “1.” From the four different haplogroups, A (0–0–0) is the most ancestral one. Nonrecurrent mutation events at T1, T2, and T3 result in the derived haplogroups B (0–1–0), C (0–1–1), and D (1–1–1). B, Within each haplogroup, a large number of different STR-defined haplotypes can be distinguished. The STR haplotype of the haplogroup A Y chromosome, from which at time T1 the first haplogroup B arose, defines the ancestral STR status of all subsequent B Y lineages. Because of a number of successive ultimate genetic bottleneck events (from a single chromosome, a whole new group of chromosomes grows), two additional Y haplogroups are born at times T2 and T3.
Figure 2
Figure 2
Genotyping results of three Y UMEs and 6 Y-STR loci among Dutch male subjects. A, A maximum parsimony tree connecting four Y haplogroups observed in 261 Dutch male subjects. Haplogroup frequencies are indicated below each pie. Nomenclature of these UME-defined haplogroups is according to Jobling and Tyler-Smith (2000). B, A median-joining network (Bandelt et al. 1999) connecting Y-STR haplotypes. In the 261 male subjects, only the 16 most frequently observed haplotypes (i.e., those shared between three or more male subjects) are illustrated. These 16 haplotypes occurred in a total of 126 (48%) male subjects. The diameter of each circle corresponds to a categorical absolute frequency (n=3–5, n=6–15, or n=16–25). Multiple colored pies indicate haplotypes that are found in different haplogroups. Within each pie, again, the absolute frequency is indicated. Unblackened circles indicate missing haplotypes. Circles are connected by single STR-repeat mutation steps. C, A median joining network connecting Y lineages. In the same 126 male subjects, 28 distinct Y lineages could be identified. The diameter of each circle corresponds to a categorical absolute frequency (n=3–5, n=6–15, or n=16–25). Unblackened circles indicate missing haplotypes. Circles are connected by single STR mutation steps or by single UME mutation steps.
Figure 3
Figure 3
Allele frequency distribution of the Y STRs DYS390 and DYS392 in 261 Dutch male subjects. The frequencies in the total sample (n=261), in haplogroup 1 male subjects (see fig. 2; n=142), and in haplogroup 2 male subjects (n=93) are shown. Colors correspond to those in figure 2. The blue/green hatched box of the total sample represents the relative contribution of haplogroup 3 and 26 male subjects.
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References

Electronic-Database Information

    1. BUGS Analyses, http://www.maths.abdn.ac.uk/~ijw/ (for BATWING)

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