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. 1975 Oct;28(10):727-32.
doi: 10.7164/antibiotics.28.727.

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization

S N Sehgal, H Baker, C Vézina
Free article

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization

S N Sehgal et al. J Antibiot (Tokyo). 1975 Oct.
Free article

Abstract

Rapamycin is a new antifungal antibiotic produced by Streptomyces hygroscopicus NRRL 5491. It was isolated from the mycelium by solvent extraction, purified by silica gel column chromatography and crystallized as a colorless solid which melts at 183 approximately to 185 degrees C and has the empirical formula C56H89NO14. From its characteristic ultraviolet absorption spectrum rapamycin can be classified as a triene. It is highly active against various Candida species, especially Candida albicans. Its activity is compared with that of amphotericin B, candicidin and nystatin.

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